BAIT

RVB1

TIH1, TIP49, TIP49A, RuvB family ATP-dependent DNA helicase pontin, S000007843, YDR190C
ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly
Saccharomyces cerevisiae (S288c)
PREY

BCD1

YHR040W
Essential protein required for the accumulation of box C/D snoRNA
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Far Western

An interaction is detected between a protein immobilized on a membrane and a purified protein probe.

Publication

A conserved Bcd1 interaction essential for box C/D snoRNP biogenesis.

Khoshnevis S, Dreggors RE, Hoffmann TFR, Ghalei H

Precise modification and processing of rRNAs are required for the production of ribosomes and accurate translation of proteins. Small nucleolar ribonucleoproteins (snoRNPs) guide the folding, modification, and processing of rRNAs and are thus critical for all eukaryotic cells. Bcd1, an essential zinc finger HIT protein functionally conserved in eukaryotes, has been implicated as an early regulator for biogenesis of box ... [more]

J. Biol. Chem. Sep. 19, 2019; (); [Pubmed: 31537647]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
RVB1 BCD1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.2899BioGRID
1926305

Curated By

  • BioGRID