BAIT
FBXW7
1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
F-box and WD-40 domain protein 7
GO Process (18)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- Notch signaling pathway [IDA]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IBA, ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to UV [ISO]
- lung development [IMP]
- negative regulation of DNA endoreduplication [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of epidermal growth factor-activated receptor activity [ISO]
- positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- positive regulation of proteasomal protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- protein stabilization [ISO]
- protein ubiquitination [ISA, ISO]
- regulation of transcription, DNA-templated [IDA]
- sister chromatid cohesion [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ITGA3
AA407068, CD49C, GAPB3, RP23-112C19.6
integrin alpha 3
GO Process (21)
GO Function (9)
GO Component (16)
Gene Ontology Biological Process
- cell adhesion [ISO]
- dendritic spine maintenance [IGI, IMP]
- exploration behavior [IGI]
- fusion of sperm to egg plasma membrane [IMP]
- lung development [ISO]
- memory [IMP]
- negative regulation of Rho protein signal transduction [IGI]
- negative regulation of cell projection organization [ISO]
- nephron development [ISO]
- neuron migration [IMP]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of neuron projection development [ISO]
- regulation of BMP signaling pathway [ISO]
- regulation of Wnt signaling pathway [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- renal filtration [ISO]
- single-organism behavior [IMP]
- skin development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basolateral plasma membrane [IDA]
- cell periphery [ISO]
- cell surface [ISO]
- excitatory synapse [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- integrin alpha3-beta1 complex [ISO]
- invadopodium membrane [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- synapse [IDA]
- synaptic membrane [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.
Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the survival of stem cell-like cells referred to as cancer stem-like cells (CSCs). The origin of CSCs is linked to the epithelial-mesenchymal transition (EMT) process. Currently, it remains poorly understood how EMT programmes enable CSCs residing in the tumour microenvironment to escape the effects of chemotherapy. This study identifies a ... [more]
Oncogenesis Feb. 19, 2019; 8(3);13 [Pubmed: 30783098]
Throughput
- High Throughput
Curated By
- BioGRID