BAIT
FBXW7
1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
F-box and WD-40 domain protein 7
GO Process (18)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- Notch signaling pathway [IDA]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IBA, ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to UV [ISO]
- lung development [IMP]
- negative regulation of DNA endoreduplication [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of epidermal growth factor-activated receptor activity [ISO]
- positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- positive regulation of proteasomal protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- protein stabilization [ISO]
- protein ubiquitination [ISA, ISO]
- regulation of transcription, DNA-templated [IDA]
- sister chromatid cohesion [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DEK
1810019E15Rik, D13H6S231E
DEK oncogene (DNA binding)
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.
Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the survival of stem cell-like cells referred to as cancer stem-like cells (CSCs). The origin of CSCs is linked to the epithelial-mesenchymal transition (EMT) process. Currently, it remains poorly understood how EMT programmes enable CSCs residing in the tumour microenvironment to escape the effects of chemotherapy. This study identifies a ... [more]
Oncogenesis Feb. 19, 2019; 8(3);13 [Pubmed: 30783098]
Throughput
- High Throughput
Curated By
- BioGRID