BAIT
FBXW7
1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
F-box and WD-40 domain protein 7
GO Process (18)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- Notch signaling pathway [IDA]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IBA, ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to UV [ISO]
- lung development [IMP]
- negative regulation of DNA endoreduplication [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of epidermal growth factor-activated receptor activity [ISO]
- positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- positive regulation of proteasomal protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- protein stabilization [ISO]
- protein ubiquitination [ISA, ISO]
- regulation of transcription, DNA-templated [IDA]
- sister chromatid cohesion [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRDX6
1-cysPrx, 9430088D19Rik, AA690119, Aop2, Aop2-rs3, Brp-12, CC26, CP-3, GPx, Ltw-4, Ltw4, Lvtw-4, NSGP, NSGPx, ORF06, Prdx5, Prdx6-rs3, aiPLA2, mKIAA0106
peroxiredoxin 6
GO Process (6)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.
Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the survival of stem cell-like cells referred to as cancer stem-like cells (CSCs). The origin of CSCs is linked to the epithelial-mesenchymal transition (EMT) process. Currently, it remains poorly understood how EMT programmes enable CSCs residing in the tumour microenvironment to escape the effects of chemotherapy. This study identifies a ... [more]
Oncogenesis Feb. 19, 2019; 8(3);13 [Pubmed: 30783098]
Throughput
- High Throughput
Curated By
- BioGRID