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BAIT

FBXW7

1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10

F-box and WD-40 domain protein 7

GO Process (18)

GO Function (7)

GO Component (10)

Gene Ontology Biological Process

Notch signaling pathway [IDA]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IBA, ISO]

cellular response to DNA damage stimulus [ISO]

cellular response to UV [ISO]

lung development [IMP]

negative regulation of DNA endoreduplication [ISO]

positive regulation of ERK1 and ERK2 cascade [ISO]

positive regulation of epidermal growth factor-activated receptor activity [ISO]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]

positive regulation of proteasomal protein catabolic process [ISO]

positive regulation of protein ubiquitination [ISO]

positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]

positive regulation of ubiquitin-protein transferase activity [ISO]

protein stabilization [ISO]

protein ubiquitination [ISA, ISO]

regulation of transcription, DNA-templated [IDA]

sister chromatid cohesion [ISO]

vasculogenesis [IMP]

Gene Ontology Molecular Function

cyclin binding [ISO]
identical protein binding [ISO]
protein binding [IPI]
protein binding, bridging [ISO]
sequence-specific DNA binding transcription factor activity [IDA]
ubiquitin protein ligase binding [ISO]
ubiquitin-protein transferase activator activity [ISO]

Gene Ontology Cellular Component

Golgi apparatus [IDA]

Parkin-FBXW7-Cul1 ubiquitin ligase complex [ISO]

SCF ubiquitin ligase complex [ISO]

cytoplasm [ISO, TAS]

endoplasmic reticulum [IDA]

nucleolus [ISO]

nucleoplasm [ISO]

nucleus [IDA, TAS]

perinuclear region of cytoplasm [IDA]

protein complex [ISO]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

CDC16

2700071J12Rik, 2810431D22Rik, APC6

CDC16 cell division cycle 16

GO Process (1)

GO Function (1)

GO Component (5)

Gene Ontology Biological Process

protein K11-linked ubiquitination [ISO]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

anaphase-promoting complex [ISO]

centrosome [ISO]

cytoplasm [ISO]

spindle microtubule [ISO]

CRISPR Database VEGA MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

Li N, Babaei-Jadidi R, Lorenzi F, Spencer-Dene B, Clarke P, Domingo E, Tulchinsky E, Vries RGJ, Kerr D, Pan Y, He Y, Bates DO, Tomlinson I, Clevers H, Nateri AS

Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the survival of stem cell-like cells referred to as cancer stem-like cells (CSCs). The origin of CSCs is linked to the epithelial-mesenchymal transition (EMT) process. Currently, it remains poorly understood how EMT programmes enable CSCs residing in the tumour microenvironment to escape the effects of chemotherapy. This study identifies a ... [more]

Oncogenesis Feb. 19, 2019; 8(3);13 [Pubmed: 30783098]

Throughput

High Throughput

Curated By

BioGRID