BAIT
BMP7
OP-1, RP11-560A15.5
bone morphogenetic protein 7
GO Process (38)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- SMAD protein signal transduction [IDA]
- cellular response to hypoxia [ISS]
- dendrite development [TAS]
- epithelial to mesenchymal transition [TAS]
- extracellular matrix organization [TAS]
- mesenchymal cell differentiation [IDA]
- mesenchyme development [ISS]
- mesonephros development [IEP]
- metanephros development [IEP]
- monocyte aggregation [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of NF-kappaB import into nucleus [ISS]
- negative regulation of NF-kappaB transcription factor activity [ISS]
- negative regulation of cell cycle [IDA]
- negative regulation of cell death [IDA]
- negative regulation of glomerular mesangial cell proliferation [IDA]
- negative regulation of mitosis [IDA]
- negative regulation of neuron differentiation [IDA]
- negative regulation of phosphorylation [IDA]
- negative regulation of striated muscle cell apoptotic process [ISS]
- negative regulation of transcription, DNA-templated [IDA]
- neuron projection morphogenesis [IDA]
- positive regulation of bone mineralization [IDA]
- positive regulation of dendrite development [IDA]
- positive regulation of heterotypic cell-cell adhesion [IDA]
- positive regulation of hyaluranon cable assembly [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, TAS]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to nucleus [IDA]
- regulation of apoptotic process [IBA]
- regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- regulation of removal of superoxide radicals [ISS]
- skeletal system development [TAS]
- steroid hormone mediated signaling pathway [IMP]
- ureteric bud development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
STUB1
CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1, LA16c-313D11.6
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
GO Process (15)
GO Function (15)
GO Component (10)
Gene Ontology Biological Process
- cellular response to misfolded protein [IDA]
- misfolded or incompletely synthesized protein catabolic process [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- positive regulation of chaperone-mediated protein complex assembly [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K63-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein maturation [TAS]
- protein polyubiquitination [IDA, IMP]
- regulation of glucocorticoid metabolic process [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
- ubiquitin-dependent SMAD protein catabolic process [IDA]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IDA]
- Hsp90 protein binding [IDA]
- SMAD binding [IDA]
- TPR domain binding [IDA]
- enzyme binding [IPI]
- kinase binding [IPI]
- misfolded protein binding [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [ISS]
- ubiquitin protein ligase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA, IMP, TAS]
- ubiquitin-ubiquitin ligase activity [ISS]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IDA]
- Hsp90 protein binding [IDA]
- SMAD binding [IDA]
- TPR domain binding [IDA]
- enzyme binding [IPI]
- kinase binding [IPI]
- misfolded protein binding [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [ISS]
- ubiquitin protein ligase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA, IMP, TAS]
- ubiquitin-ubiquitin ligase activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Bone morphogenetic protein (BMP) 7 expression is regulated by the E3 ligase UBE4A in diabetic nephropathy.
Mesangial cells played a central role in the pathophysiology of diabetic nephropathy (DN). Our goal was to evaluate the molecular mechanism that regulates loss of BMP7 protein expression in DN. The mRNA and protein levels of BMP7 or UBE4A were detected using qRT-PCR and Western blot respectively. Mass spectrometry and co-immunoprecipitation were used to explore the E3 ligase which regulated ... [more]
Arch. Physiol. Biochem. Jan. 19, 2019; ();1-4 [Pubmed: 30663414]
Throughput
- High Throughput
Curated By
- BioGRID