ARAF
Gene Ontology Biological Process
Gene Ontology Molecular Function
NANOG
Gene Ontology Biological Process
- cell differentiation [IEP]
- cell proliferation [IMP]
- endodermal cell fate specification [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell differentiation [IMP]
- regulation of gene expression [IMP]
- regulation of transcription, DNA-templated [IDA]
- somatic stem cell maintenance [IMP]
- stem cell maintenance [IEP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.
NANOG is an essential transcriptional factor for the maintenance of embryonic stem cells (ESCs) and cancer stem cells (CSCs) in prostate cancer (PCa). However, the regulation mechanism of NANOG protein stability in cancer progression is still elusive. Here, we report that NANOG is degraded by SPOP, a frequently mutated tumor suppressor of PCa. Cancer-associated mutations of SPOP or the mutation ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID