BAIT
SENP8
DEN1, NEDP1, PRSC2, FKSG8
SUMO/sentrin specific peptidase family member 8
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CRBN
MRT2, MRT2A, AD-006
cereblon
GO Process (2)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Dosage Growth Defect
A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene.
Publication
Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma.
Genome-wide CRISPR/Cas9 screens represent a powerful approach to studying mechanisms of drug action and resistance. Cereblon modulating agents (CMs) have recently emerged as candidates for therapeutic intervention in primary effusion lymphoma (PEL), a highly aggressive cancer caused by Kaposi's sarcoma-associated herpesvirus. CMs bind to cereblon (CRBN), the substrate receptor of the cullin-RING type E3 ubiquitin ligase CRL4CRBN, and thereby trigger ... [more]
Blood Adv Jul. 23, 2019; 3(14);2105-2117 [Pubmed: 31300418]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (PATO:0000169)
- biological process: response to drug (GO:0042493)
Additional Notes
- CRISPR method
- Overexpression of CRBN restores LEN sensitivity in SENP8-inactivated cells.
Curated By
- BioGRID