An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.

Tian Y, Chang JC, Fan EY, Flajolet M, Greengard P

The hallmarks of Alzheimer's disease (AD) are the aggregates of amyloid-? (A?) peptides and tau protein. Autophagy is a major cellular pathway leading to the removal of aggregated proteins. We have reported recently that autophagy was responsible for amyloid precursor protein cleaved C-terminal fragment (APP-CTF) degradation and amyloid ? clearance in an Atg5-dependent manner. Here we aimed to elucidate the ... [more]

Proc. Natl. Acad. Sci. U.S.A. Oct. 15, 2013; 110(42);17071-6 [Pubmed: 24067654]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

MAP1LC3A

Gene Ontology Biological Process

Gene Ontology Molecular Function

GABA receptor binding [IBA]microtubule binding [IBA]phosphatidylethanolamine binding [IDA]phospholipid binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

SEC16A