AGO1
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- chromatin silencing by small RNA [IMP]
- co-transcriptional gene silencing by RNA interference machinery [IMP]
- conversion of ds siRNA to ss siRNA involved in RNA interference [IMP]
- heterochromatin assembly involved in chromatin silencing by small RNA [IMP]
- mitotic sister chromatid segregation [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of chromatin silencing at centromere [IMP]
- regulation of histone H3-K9 methylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HHT3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Regulation of transcriptional silencing and chromodomain protein localization at centromeric heterochromatin by histone H3 tyrosine 41 phosphorylation in fission yeast.
Heterochromatin silencing is critical for genomic integrity and cell survival. It is orchestrated by chromodomain (CD)-containing proteins that bind to methylated histone H3 lysine 9 (H3K9me), a hallmark of heterochromatin. Here, we show that phosphorylation of tyrosine 41 (H3Y41p)-a novel histone H3 modification-participates in the regulation of heterochromatin in fission yeast. We show that a loss-of-function mutant of H3Y41 can ... [more]
Throughput
- Low Throughput
Ontology Terms
- silencing (APO:0000046)
Additional Notes
- H3Y41F
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AGO1 HHT3 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 1.8157 | BioGRID | 756543 | |
| AGO1 HHT3 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 2617128 |
Curated By
- BioGRID