BAIT
RELA
p65
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
GO Process (41)
GO Function (25)
GO Component (8)
Gene Ontology Biological Process
- NIK/NF-kappaB signaling [IBA]
- cellular response to hydrogen peroxide [ISO]
- cellular response to interleukin-1 [ISO]
- cellular response to interleukin-6 [ISO]
- cellular response to nicotine [ISO]
- cellular response to peptide hormone stimulus [ISO]
- cellular response to stress [IBA]
- cellular response to tumor necrosis factor [ISO]
- cytokine-mediated signaling pathway [ISO]
- defense response [IMP]
- hair follicle development [IMP]
- inflammatory response [ISO]
- innate immune response [IBA]
- liver development [IMP]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IDA, ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [ISO]
- organ morphogenesis [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA, ISO]
- positive regulation of Schwann cell differentiation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of interleukin-12 biosynthetic process [IDA]
- positive regulation of miRNA metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO, TAS]
- regulation of inflammatory response [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to UV-B [ISO]
- response to bacterium [IDA]
- response to cytokine [IBA]
- response to interleukin-1 [ISO]
- response to muramyl dipeptide [IDA]
- response to muscle stretch [IDA]
- response to organic substance [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISO]
- ankyrin repeat binding [IPI]
- chromatin binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- phosphate ion binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA, ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISO]
- ankyrin repeat binding [IPI]
- chromatin binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- phosphate ion binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
HDAC1
HD1, Hdac1-ps, MommeD5, RPD3, RP23-209C6.7
histone deacetylase 1
GO Process (42)
GO Function (24)
GO Component (16)
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [ISO]
- cellular response to oxidative stress [ISO]
- chromatin modification [TAS]
- circadian regulation of gene expression [IDA]
- circadian rhythm [IDA]
- embryonic digit morphogenesis [IGI]
- endoderm development [IDA, IMP]
- epidermal cell differentiation [IGI]
- eyelid development in camera-type eye [IGI]
- fungiform papilla formation [IGI]
- hair follicle placode formation [IGI]
- hippocampus development [IGI]
- histone H3 deacetylation [IDA, ISO]
- histone H4 deacetylation [IDA, ISO]
- histone deacetylation [ISO]
- negative regulation by host of viral transcription [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IGI]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [IGI]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of cell proliferation [ISO]
- negative regulation of insulin secretion [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IGI]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of peptidyl-lysine acetylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neuron differentiation [IGI]
- odontogenesis of dentin-containing tooth [IGI]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [ISO]
- positive regulation of interleukin-1 production [ISO]
- positive regulation of oligodendrocyte differentiation [IGI, ISO]
- positive regulation of receptor biosynthetic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of type B pancreatic cell apoptotic process [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- protein deacetylation [ISO]
- response to amphetamine [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- Krueppel-associated box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II repressing transcription factor binding [IPI, ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA, ISO]
- core promoter binding [IDA, ISO]
- deacetylase activity [IDA]
- enzyme binding [ISO]
- histone deacetylase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- nucleosomal DNA binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein deacetylase activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [ISO, TAS]
- transcription regulatory region DNA binding [ISO]
- transcription regulatory region sequence-specific DNA binding [IDA]
- DNA binding [IDA]
- Krueppel-associated box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II repressing transcription factor binding [IPI, ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA, ISO]
- core promoter binding [IDA, ISO]
- deacetylase activity [IDA]
- enzyme binding [ISO]
- histone deacetylase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- nucleosomal DNA binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein deacetylase activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [ISO, TAS]
- transcription regulatory region DNA binding [ISO]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
- NuRD complex [IDA, IPI, ISO]
- Sin3 complex [ISO]
- chromatin [ISO]
- cytoplasm [TAS]
- cytosol [ISO]
- heterochromatin [IDA]
- histone deacetylase complex [IPI, TAS]
- neuron projection [ISO]
- neuronal cell body [IDA]
- nuclear chromatin [IDA, ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [IDA, ISO]
- transcription factor complex [IDA, IPI]
- transcriptional repressor complex [IPI]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.
Homodimers of the NF-kappa B p50 subunit are transcriptionally repressive in cells, whereas they can promote transcription in vitro, suggesting that their endogenous effects are mediated by association with other factors. We now demonstrate that transcriptionally inactive nuclear NF-kappaB in resting cells consists of homodimers of either p65 or p50 complexed with the histone deacetylase HDAC-1. Only the p50-HDAC-1 complexes ... [more]
Mol. Cell Mar. 01, 2002; 9(3);625-36 [Pubmed: 11931769]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HDAC1 RELA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID