BAIT
PRDM16
CMD1LL, LVNC8, MEL1, PFM13
PR domain containing 16
GO Process (7)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- brown fat cell differentiation [ISS]
- negative regulation of granulocyte differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- regulation of cellular respiration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BAZ1B
WBSCR10, WBSCR9, WSTF
bromodomain adjacent to zinc finger domain, 1B
GO Process (8)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA]
- chromatin-mediated maintenance of transcription [ISS]
- double-strand break repair [ISS]
- heart morphogenesis [ISS]
- histone phosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- regulation of transcription, DNA-templated [ISS]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.
Aberrant isoform expression of chromatin-associated proteins can induce epigenetic programs related to disease. The MDS1 and EVI1 complex locus (MECOM) encodes PRDM3, a protein with an N-terminal PR-SET domain, as well as a shorter isoform, EVI1, lacking the N-terminus containing the PR-SET domain (?PR). Imbalanced expression of MECOM isoforms is observed in multiple malignancies, implicating EVI1 as an oncogene, while ... [more]
Nucleic Acids Res. Dec. 20, 2018; 47(3);1225-1238 [Pubmed: 30462309]
Throughput
- High Throughput
Additional Notes
- PRDM16
- high confidence interactors have a BDFR=/<0.01
Curated By
- BioGRID