An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.

Li J, Cheng D, Zhu M, Yu H, Pan Z, Liu L, Geng Q, Pan H, Yan M, Yao M

Increasing evidence has confirmed that deubiquitinating enzymes play an important role in lung cancer progression. In the current study, we investigated the expression profile of deubiquitinating enzymes in non-small cell lung cancer (NSCLC) tissues and identified OTUB2 as an upregulated deubiquitinating enzyme. The role of OTUB2 in NSCLC is unknown. Methods: Quantitative, real-time PCR and Western blot were used to ... [more]

Theranostics Jan. 22, 2019; 9(1);179-195 [Pubmed: 30662561]

Throughput

High Throughput

Additional Notes

Source of OTUB2 not clear

Curated By

BioGRID

Interaction Summary

OTUB2

Gene Ontology Biological Process

Gene Ontology Molecular Function

ubiquitin-specific protease activity [IDA, IMP]

Gene Ontology Cellular Component

EEF1A1