BAIT
DCAF15
C19orf72
DDB1 and CUL4 associated factor 15
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
EXT2
SOTV
exostosin glycosyltransferase 2
GO Process (9)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cellular polysaccharide biosynthetic process [IDA]
- glycosaminoglycan biosynthetic process [IDA, TAS]
- glycosaminoglycan metabolic process [TAS]
- heparan sulfate proteoglycan biosynthetic process [IMP]
- heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [IMP]
- ossification [IMP]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [NAS]
- acetylglucosaminyltransferase activity [IDA]
- glucuronosyltransferase activity [IDA]
- heparan sulfate N-acetylglucosaminyltransferase activity [NAS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- transferase activity, transferring glycosyl groups [IDA]
- N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [NAS]
- acetylglucosaminyltransferase activity [IDA]
- glucuronosyltransferase activity [IDA]
- heparan sulfate N-acetylglucosaminyltransferase activity [NAS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- transferase activity, transferring glycosyl groups [IDA]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.
Only a subset of cancer patients respond to T-cell checkpoint inhibitors, highlighting the need for alternative immunotherapeutics. We performed CRISPR-Cas9 screens in a leukemia cell line to identify perturbations that enhance natural killer effector functions. Our screens defined critical components of the tumor-immune synapse and highlighted the importance of cancer cell interferon-? signaling in modulating NK activity. Surprisingly, disrupting the ... [more]
Elife Dec. 27, 2018; 8(); [Pubmed: 31452512]
Throughput
- High Throughput
Curated By
- BioGRID