BAIT

DCAF15

C19orf72
DDB1 and CUL4 associated factor 15
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

MAP1B

FUTSCH, MAP5, PPP1R102
microtubule-associated protein 1B
GO Process (1)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

Pech MF, Fong LE, Villalta JE, Chan LJ, Kharbanda S, O'Brien JJ, McAllister FE, Firestone AJ, Jan CH, Settleman J

Only a subset of cancer patients respond to T-cell checkpoint inhibitors, highlighting the need for alternative immunotherapeutics. We performed CRISPR-Cas9 screens in a leukemia cell line to identify perturbations that enhance natural killer effector functions. Our screens defined critical components of the tumor-immune synapse and highlighted the importance of cancer cell interferon-? signaling in modulating NK activity. Surprisingly, disrupting the ... [more]

Elife Dec. 27, 2018; 8(); [Pubmed: 31452512]

Throughput

  • High Throughput

Curated By

  • BioGRID