BAIT
DCAF15
C19orf72
DDB1 and CUL4 associated factor 15
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
SORBS1
CAP, FLAF2, R85FL, SH3D5, SH3P12, SORB1, RP11-476E15.1
sorbin and SH3 domain containing 1
GO Process (12)
GO Function (5)
GO Component (13)
Gene Ontology Biological Process
- cell-matrix adhesion [TAS]
- cellular response to insulin stimulus [ISS]
- focal adhesion assembly [ISS]
- glucose transport [ISS]
- insulin receptor signaling pathway [ISS]
- muscle contraction [TAS]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of glucose import [ISS]
- positive regulation of glycogen biosynthetic process [ISS]
- positive regulation of lipid biosynthetic process [ISS]
- positive regulation of signal transduction [IC, ISS]
- stress fiber assembly [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.
Only a subset of cancer patients respond to T-cell checkpoint inhibitors, highlighting the need for alternative immunotherapeutics. We performed CRISPR-Cas9 screens in a leukemia cell line to identify perturbations that enhance natural killer effector functions. Our screens defined critical components of the tumor-immune synapse and highlighted the importance of cancer cell interferon-? signaling in modulating NK activity. Surprisingly, disrupting the ... [more]
Elife Dec. 27, 2018; 8(); [Pubmed: 31452512]
Throughput
- High Throughput
Curated By
- BioGRID