BAIT

DCAF15

C19orf72
DDB1 and CUL4 associated factor 15
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

EPS15L1

EPS15R
epidermal growth factor receptor pathway substrate 15-like 1
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

Pech MF, Fong LE, Villalta JE, Chan LJ, Kharbanda S, O'Brien JJ, McAllister FE, Firestone AJ, Jan CH, Settleman J

Only a subset of cancer patients respond to T-cell checkpoint inhibitors, highlighting the need for alternative immunotherapeutics. We performed CRISPR-Cas9 screens in a leukemia cell line to identify perturbations that enhance natural killer effector functions. Our screens defined critical components of the tumor-immune synapse and highlighted the importance of cancer cell interferon-? signaling in modulating NK activity. Surprisingly, disrupting the ... [more]

Elife Dec. 27, 2018; 8(); [Pubmed: 31452512]

Throughput

  • High Throughput

Curated By

  • BioGRID