DYRK2
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IEP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- negative regulation of NFAT protein import into nucleus [IMP]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of glycogen biosynthetic process [IDA]
- protein phosphorylation [IDA]
- smoothened signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EIF2B5
Gene Ontology Biological Process
- astrocyte development [IMP]
- astrocyte differentiation [IMP]
- cellular protein metabolic process [TAS]
- cellular response to drug [IDA]
- gene expression [TAS]
- myelination [IMP]
- negative regulation of translational initiation in response to stress [ISS]
- oligodendrocyte development [IMP]
- ovarian follicle development [IMP]
- positive regulation of GTPase activity [IDA, IMP, ISS]
- positive regulation of translational initiation [ISS]
- response to endoplasmic reticulum stress [IMP]
- response to glucose [ISS]
- response to heat [IMP, ISS, TAS]
- response to peptide hormone [ISS]
- translation [TAS]
- translational initiation [IDA, TAS]
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.
The substrate specificity of glycogen synthase kinase 3 (GSK3) is unusual in that efficient phosphorylation only occurs if another phosphoserine or phosphothreonine residue is already present four residues C-terminal to the site of GSK3 phosphorylation. One such substrate is the epsilon-subunit of rat eukaryotic protein-synthesis initiation factor 2B (eIF2Bepsilon), which is inhibited by the GSK3-catalysed phosphorylation of Ser(535). There is ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID