PDE10A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AKAP5
Gene Ontology Biological Process
- cellular protein complex disassembly [ISO]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of ion transport [ISO]
- negative regulation of potassium ion transport [ISO]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of adenylate cyclase activity [ISO]
- positive regulation of cAMP biosynthetic process [ISO]
- positive regulation of calcium ion transport into cytosol [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- positive regulation of protein kinase A signaling [ISO]
- positive regulation of protein phosphorylation [ISO]
Gene Ontology Molecular Function- G-protein coupled receptor binding [ISO]
- GABA receptor binding [ISO]
- actin binding [ISO]
- adenylate cyclase binding [ISO]
- cadherin binding [ISO]
- kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2B binding [ISO]
- G-protein coupled receptor binding [ISO]
- GABA receptor binding [ISO]
- actin binding [ISO]
- adenylate cyclase binding [ISO]
- cadherin binding [ISO]
- kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2B binding [ISO]
Gene Ontology Cellular Component
- asymmetric synapse [ISO]
- basolateral plasma membrane [ISO]
- cytoplasm [ISO]
- dendrite membrane [ISO]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- dendritic spine membrane [ISO]
- filopodium membrane [ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum.
Phosphodiesterase 10A (PDE10A) is a dual substrate PDE that can hydrolyze both cGMP and cAMP. In brain, PDE10A is almost exclusively expressed in the striatum. In several studies, PDE10A has been implicated in regulation of striatal output using either specific inhibitors or PDE10A knock-out mice and has been suggested as a promising target for novel antipsychotic drugs. In striatal medium ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AKAP5 PDE10A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID