BAIT
TRPV1
OTRPC1, TRPV1alpha, TRPV1beta, VR-1, Vr1, RP23-214D6.2
transient receptor potential cation channel, subfamily V, member 1
GO Process (33)
GO Function (13)
GO Component (11)
Gene Ontology Biological Process
- behavioral response to pain [IMP]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IDA, IMP, ISO]
- catagen [IMP]
- cation transmembrane transport [ISA]
- cation transport [ISA]
- cellular response to ATP [ISO]
- cellular response to alkaloid [ISO]
- cellular response to cytokine stimulus [ISO]
- detection of chemical stimulus involved in sensory perception of pain [IDA, IMP]
- diet induced thermogenesis [IMP]
- fever generation [IMP]
- glutamate secretion [ISO]
- ion transmembrane transport [IDA]
- lipid metabolic process [IMP]
- microglial cell activation [ISO]
- negative regulation of establishment of blood-brain barrier [ISO]
- peptide secretion [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gastric acid secretion [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- response to heat [IMP, ISO]
- response to organonitrogen compound [IMP]
- response to pH [IMP, ISO]
- response to pain [IDA, IMP]
- sensory perception of mechanical stimulus [IMP]
- sensory perception of pain [IMP]
- signal transduction [ISO]
- smooth muscle contraction involved in micturition [IMP]
- temperature homeostasis [IMP]
- thermoception [ISO]
- urinary bladder smooth muscle contraction [IMP]
Gene Ontology Molecular Function- ATP binding [ISO]
- calcium channel activity [IMP]
- calcium-release channel activity [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISA, ISO]
- cation transmembrane transporter activity [ISO]
- chloride channel regulator activity [ISO]
- excitatory extracellular ligand-gated ion channel activity [ISO]
- identical protein binding [ISO]
- ion channel activity [IDA]
- ligand-gated ion channel activity [ISO]
- phosphoprotein binding [ISO]
- transmembrane signaling receptor activity [ISO]
- ATP binding [ISO]
- calcium channel activity [IMP]
- calcium-release channel activity [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISA, ISO]
- cation transmembrane transporter activity [ISO]
- chloride channel regulator activity [ISO]
- excitatory extracellular ligand-gated ion channel activity [ISO]
- identical protein binding [ISO]
- ion channel activity [IDA]
- ligand-gated ion channel activity [ISO]
- phosphoprotein binding [ISO]
- transmembrane signaling receptor activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
CHMP4B
2010012F05Rik, C76846, Snf7-2, RP23-29D15.3
charged multivesicular body protein 4B
GO Process (8)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- negative regulation of autophagic vacuole assembly [ISO]
- negative regulation of neuron death [ISO]
- positive regulation of viral release from host cell [ISO]
- posttranslational protein targeting to membrane [ISO]
- protein homooligomerization [ISO]
- regulation of viral process [ISO]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [ISO]
- viral budding via host ESCRT complex [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Vti1b promotes TRPV1 sensitization during inflammatory pain.
Sensitization of the transient receptor potential ion channel vanilloid 1 (TRPV1) is critically involved in inflammatory pain. To date, manifold signaling cascades have been shown to converge onto TRPV1 and enhance its sensitization. However, many of them also play a role for nociceptive pain, which limits their utility as targets for therapeutic intervention. Here, we show that the vesicle transport ... [more]
Pain Feb. 01, 2019; 160(2);508-527 [Pubmed: 30335684]
Throughput
- High Throughput
Curated By
- BioGRID