BAIT
TRPV1
OTRPC1, TRPV1alpha, TRPV1beta, VR-1, Vr1, RP23-214D6.2
transient receptor potential cation channel, subfamily V, member 1
GO Process (33)
GO Function (13)
GO Component (11)
Gene Ontology Biological Process
- behavioral response to pain [IMP]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IDA, IMP, ISO]
- catagen [IMP]
- cation transmembrane transport [ISA]
- cation transport [ISA]
- cellular response to ATP [ISO]
- cellular response to alkaloid [ISO]
- cellular response to cytokine stimulus [ISO]
- detection of chemical stimulus involved in sensory perception of pain [IDA, IMP]
- diet induced thermogenesis [IMP]
- fever generation [IMP]
- glutamate secretion [ISO]
- ion transmembrane transport [IDA]
- lipid metabolic process [IMP]
- microglial cell activation [ISO]
- negative regulation of establishment of blood-brain barrier [ISO]
- peptide secretion [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gastric acid secretion [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- response to heat [IMP, ISO]
- response to organonitrogen compound [IMP]
- response to pH [IMP, ISO]
- response to pain [IDA, IMP]
- sensory perception of mechanical stimulus [IMP]
- sensory perception of pain [IMP]
- signal transduction [ISO]
- smooth muscle contraction involved in micturition [IMP]
- temperature homeostasis [IMP]
- thermoception [ISO]
- urinary bladder smooth muscle contraction [IMP]
Gene Ontology Molecular Function- ATP binding [ISO]
- calcium channel activity [IMP]
- calcium-release channel activity [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISA, ISO]
- cation transmembrane transporter activity [ISO]
- chloride channel regulator activity [ISO]
- excitatory extracellular ligand-gated ion channel activity [ISO]
- identical protein binding [ISO]
- ion channel activity [IDA]
- ligand-gated ion channel activity [ISO]
- phosphoprotein binding [ISO]
- transmembrane signaling receptor activity [ISO]
- ATP binding [ISO]
- calcium channel activity [IMP]
- calcium-release channel activity [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISA, ISO]
- cation transmembrane transporter activity [ISO]
- chloride channel regulator activity [ISO]
- excitatory extracellular ligand-gated ion channel activity [ISO]
- identical protein binding [ISO]
- ion channel activity [IDA]
- ligand-gated ion channel activity [ISO]
- phosphoprotein binding [ISO]
- transmembrane signaling receptor activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
DAB2
5730435J12Rik, AA960054, AI957090, D15Wsu122e, D630005B22Rik, Doc-2, Doc2, p96, mCG_144967
disabled 2, mitogen-responsive phosphoprotein
GO Process (43)
GO Function (10)
GO Component (14)
Gene Ontology Biological Process
- activation of JUN kinase activity [IDA]
- cell morphogenesis involved in differentiation [IMP]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [IDA]
- clathrin coat assembly [IDA, ISO]
- endoderm development [IMP]
- excretion [IMP]
- in utero embryonic development [IMP]
- leading edge cell differentiation [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of neuron projection development [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein localization to plasma membrane [IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- pinocytosis [IMP]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of Wnt signaling pathway, planar cell polarity pathway [ISO]
- positive regulation of aldosterone biosynthetic process [ISO]
- positive regulation of aldosterone secretion [ISO]
- positive regulation of cell adhesion [IDA, IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of clathrin-mediated endocytosis [IDA, ISO]
- positive regulation of early endosome to late endosome transport [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of epithelial to mesenchymal transition [IMP, ISO]
- positive regulation of integrin-mediated signaling pathway [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP, ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of receptor recycling [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IDA, IMP, ISO]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- receptor-mediated endocytosis [IDA, IPI, ISO]
- regulation of Rho-dependent protein serine/threonine kinase activity [ISO]
- response to steroid hormone [ISO]
Gene Ontology Molecular Function- AP-2 adaptor complex binding [IDA]
- SMAD binding [ISO]
- cargo receptor activity [IDA, ISO]
- clathrin adaptor activity [IDA, ISO]
- clathrin binding [IDA]
- integrin binding [IMP]
- phosphatidylinositol binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- AP-2 adaptor complex binding [IDA]
- SMAD binding [ISO]
- cargo receptor activity [IDA, ISO]
- clathrin adaptor activity [IDA, ISO]
- clathrin binding [IDA]
- integrin binding [IMP]
- phosphatidylinositol binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- clathrin coat of coated pit [IDA]
- clathrin-coated vesicle [ISO]
- clathrin-coated vesicle membrane [ISO]
- coated pit [ISO]
- cytoplasm [IDA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- nucleolus [ISO]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- transforming growth factor beta receptor homodimeric complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Vti1b promotes TRPV1 sensitization during inflammatory pain.
Sensitization of the transient receptor potential ion channel vanilloid 1 (TRPV1) is critically involved in inflammatory pain. To date, manifold signaling cascades have been shown to converge onto TRPV1 and enhance its sensitization. However, many of them also play a role for nociceptive pain, which limits their utility as targets for therapeutic intervention. Here, we show that the vesicle transport ... [more]
Pain Feb. 01, 2019; 160(2);508-527 [Pubmed: 30335684]
Throughput
- High Throughput
Curated By
- BioGRID