BAIT
TRPV1
OTRPC1, TRPV1alpha, TRPV1beta, VR-1, Vr1, RP23-214D6.2
transient receptor potential cation channel, subfamily V, member 1
GO Process (33)
GO Function (13)
GO Component (11)
Gene Ontology Biological Process
- behavioral response to pain [IMP]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IDA, IMP, ISO]
- catagen [IMP]
- cation transmembrane transport [ISA]
- cation transport [ISA]
- cellular response to ATP [ISO]
- cellular response to alkaloid [ISO]
- cellular response to cytokine stimulus [ISO]
- detection of chemical stimulus involved in sensory perception of pain [IDA, IMP]
- diet induced thermogenesis [IMP]
- fever generation [IMP]
- glutamate secretion [ISO]
- ion transmembrane transport [IDA]
- lipid metabolic process [IMP]
- microglial cell activation [ISO]
- negative regulation of establishment of blood-brain barrier [ISO]
- peptide secretion [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gastric acid secretion [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- response to heat [IMP, ISO]
- response to organonitrogen compound [IMP]
- response to pH [IMP, ISO]
- response to pain [IDA, IMP]
- sensory perception of mechanical stimulus [IMP]
- sensory perception of pain [IMP]
- signal transduction [ISO]
- smooth muscle contraction involved in micturition [IMP]
- temperature homeostasis [IMP]
- thermoception [ISO]
- urinary bladder smooth muscle contraction [IMP]
Gene Ontology Molecular Function- ATP binding [ISO]
- calcium channel activity [IMP]
- calcium-release channel activity [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISA, ISO]
- cation transmembrane transporter activity [ISO]
- chloride channel regulator activity [ISO]
- excitatory extracellular ligand-gated ion channel activity [ISO]
- identical protein binding [ISO]
- ion channel activity [IDA]
- ligand-gated ion channel activity [ISO]
- phosphoprotein binding [ISO]
- transmembrane signaling receptor activity [ISO]
- ATP binding [ISO]
- calcium channel activity [IMP]
- calcium-release channel activity [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISA, ISO]
- cation transmembrane transporter activity [ISO]
- chloride channel regulator activity [ISO]
- excitatory extracellular ligand-gated ion channel activity [ISO]
- identical protein binding [ISO]
- ion channel activity [IDA]
- ligand-gated ion channel activity [ISO]
- phosphoprotein binding [ISO]
- transmembrane signaling receptor activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
FLNA
ABP-280, Dilp2, F730004A14Rik, Fln1, GENA 379, filamin-1, RP23-436K3.1
filamin, alpha
GO Process (19)
GO Function (16)
GO Component (18)
Gene Ontology Biological Process
- actin crosslink formation [ISO]
- actin cytoskeleton organization [IGI]
- actin cytoskeleton reorganization [ISO]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [ISO]
- cilium assembly [ISO]
- cytoplasmic sequestering of protein [ISO]
- early endosome to late endosome transport [IDA]
- epithelial to mesenchymal transition [IGI]
- establishment of protein localization [ISO]
- mRNA transcription from RNA polymerase II promoter [ISO]
- negative regulation of protein catabolic process [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- platelet aggregation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- protein localization to cell surface [ISO]
- protein stabilization [ISO]
- receptor clustering [ISO]
- spindle assembly involved in mitosis [ISO]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Myb complex [ISO]
- actin cytoskeleton [ISO]
- actin filament [ISO]
- actin filament bundle [IDA]
- apical dendrite [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendritic shaft [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- trans-Golgi network [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Vti1b promotes TRPV1 sensitization during inflammatory pain.
Sensitization of the transient receptor potential ion channel vanilloid 1 (TRPV1) is critically involved in inflammatory pain. To date, manifold signaling cascades have been shown to converge onto TRPV1 and enhance its sensitization. However, many of them also play a role for nociceptive pain, which limits their utility as targets for therapeutic intervention. Here, we show that the vesicle transport ... [more]
Pain Feb. 01, 2019; 160(2);508-527 [Pubmed: 30335684]
Throughput
- High Throughput
Curated By
- BioGRID