BAIT
TRPV1
OTRPC1, TRPV1alpha, TRPV1beta, VR-1, Vr1, RP23-214D6.2
transient receptor potential cation channel, subfamily V, member 1
GO Process (33)
GO Function (13)
GO Component (11)
Gene Ontology Biological Process
- behavioral response to pain [IMP]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IDA, IMP, ISO]
- catagen [IMP]
- cation transmembrane transport [ISA]
- cation transport [ISA]
- cellular response to ATP [ISO]
- cellular response to alkaloid [ISO]
- cellular response to cytokine stimulus [ISO]
- detection of chemical stimulus involved in sensory perception of pain [IDA, IMP]
- diet induced thermogenesis [IMP]
- fever generation [IMP]
- glutamate secretion [ISO]
- ion transmembrane transport [IDA]
- lipid metabolic process [IMP]
- microglial cell activation [ISO]
- negative regulation of establishment of blood-brain barrier [ISO]
- peptide secretion [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gastric acid secretion [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- response to heat [IMP, ISO]
- response to organonitrogen compound [IMP]
- response to pH [IMP, ISO]
- response to pain [IDA, IMP]
- sensory perception of mechanical stimulus [IMP]
- sensory perception of pain [IMP]
- signal transduction [ISO]
- smooth muscle contraction involved in micturition [IMP]
- temperature homeostasis [IMP]
- thermoception [ISO]
- urinary bladder smooth muscle contraction [IMP]
Gene Ontology Molecular Function- ATP binding [ISO]
- calcium channel activity [IMP]
- calcium-release channel activity [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISA, ISO]
- cation transmembrane transporter activity [ISO]
- chloride channel regulator activity [ISO]
- excitatory extracellular ligand-gated ion channel activity [ISO]
- identical protein binding [ISO]
- ion channel activity [IDA]
- ligand-gated ion channel activity [ISO]
- phosphoprotein binding [ISO]
- transmembrane signaling receptor activity [ISO]
- ATP binding [ISO]
- calcium channel activity [IMP]
- calcium-release channel activity [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISA, ISO]
- cation transmembrane transporter activity [ISO]
- chloride channel regulator activity [ISO]
- excitatory extracellular ligand-gated ion channel activity [ISO]
- identical protein binding [ISO]
- ion channel activity [IDA]
- ligand-gated ion channel activity [ISO]
- phosphoprotein binding [ISO]
- transmembrane signaling receptor activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
MAPK1
9030612K14Rik, AA407128, AU018647, C78273, ERK, Erk2, MAPK2, PRKM2, Prkm1, p41mapk, p42mapk
mitogen-activated protein kinase 1
GO Process (35)
GO Function (12)
GO Component (18)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- ERBB signaling pathway [ISO]
- ERK1 and ERK2 cascade [ISO]
- MAPK cascade [IDA, IMP, ISO]
- MAPK import into nucleus [ISO]
- T cell receptor signaling pathway [IDA]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- cellular response to organic substance [ISO]
- cytosine metabolic process [IDA]
- intracellular signal transduction [ISO]
- labyrinthine layer blood vessel development [IMP]
- lipopolysaccharide-mediated signaling pathway [IDA]
- mammary gland epithelial cell proliferation [IDA]
- negative regulation of cell differentiation [IGI]
- organ morphogenesis [IDA]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of translation [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [NAS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO]
- response to estrogen [ISO]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- response to toxic substance [ISO]
- sensory perception of pain [ISO]
- signal transduction [ISO]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function- ATP binding [ISO]
- MAP kinase activity [IDA, IMP, ISO]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- kinase activity [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatase binding [ISO]
- phosphotyrosine binding [IMP]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ATP binding [ISO]
- MAP kinase activity [IDA, IMP, ISO]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- kinase activity [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatase binding [ISO]
- phosphotyrosine binding [IMP]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- axon [ISO]
- caveola [TAS]
- cytoplasm [IDA, ISO]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- dendrite cytoplasm [ISO]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [IDA, TAS]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, TAS]
- perikaryon [ISO]
- protein complex [ISO]
- pseudopodium [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Vti1b promotes TRPV1 sensitization during inflammatory pain.
Sensitization of the transient receptor potential ion channel vanilloid 1 (TRPV1) is critically involved in inflammatory pain. To date, manifold signaling cascades have been shown to converge onto TRPV1 and enhance its sensitization. However, many of them also play a role for nociceptive pain, which limits their utility as targets for therapeutic intervention. Here, we show that the vesicle transport ... [more]
Pain Feb. 01, 2019; 160(2);508-527 [Pubmed: 30335684]
Throughput
- High Throughput
Curated By
- BioGRID