PRMT7
Gene Ontology Biological Process
- DNA methylation involved in gamete generation [ISS]
- histone arginine methylation [IBA, ISS]
- histone methylation [IDA]
- peptidyl-arginine methylation [IDA, IMP]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- peptidyl-arginine methylation, to symmetrical-dimethyl arginine [IDA, IMP]
- regulation of gene expression by genetic imprinting [ISS]
- regulation of protein binding [IC]
- regulation of transcription, DNA-templated [IBA]
- spliceosomal snRNP assembly [IMP]
Gene Ontology Molecular Function- S-adenosylmethionine-dependent methyltransferase activity [IDA]
- [myelin basic protein]-arginine N-methyltransferase activity [IDA]
- histone binding [IC]
- histone methyltransferase activity (H4-R3 specific) [ISS]
- histone-arginine N-methyltransferase activity [IDA]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- protein-arginine omega-N monomethyltransferase activity [IDA]
- protein-arginine omega-N symmetric methyltransferase activity [IDA, IMP]
- ribonucleoprotein complex binding [IPI]
- S-adenosylmethionine-dependent methyltransferase activity [IDA]
- [myelin basic protein]-arginine N-methyltransferase activity [IDA]
- histone binding [IC]
- histone methyltransferase activity (H4-R3 specific) [ISS]
- histone-arginine N-methyltransferase activity [IDA]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- protein-arginine omega-N monomethyltransferase activity [IDA]
- protein-arginine omega-N symmetric methyltransferase activity [IDA, IMP]
- ribonucleoprotein complex binding [IPI]
Gene Ontology Cellular Component
EIF2S1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Methylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
PRMT7 methylates eukaryotic translation initiation factor 2? and regulates its role in stress granule formation.
Protein arginine methyltransferases (PRMTs) are a family of enzymes that modify proteins by methylating the guanidino nitrogen atoms of arginine residues to regulate cellular processes such as chromatin remodeling, pre-mRNA splicing, and signal transduction. PRMT7 is the single type III PRMT solely capable of arginine monomethylation. To date, other than histone proteins, there are very few identified substrates of PRMT7. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRMT7 EIF2S1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| EIF2S1 PRMT7 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3132961 | |
| PRMT7 EIF2S1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PRMT7 EIF2S1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - | |
| PRMT7 EIF2S1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2723505 |
Curated By
- BioGRID