BAIT
SASH1
SH3D6A, dJ323M4, dJ323M4.1, RP3-323M4.1
SAM and SH3 domain containing 1
GO Process (9)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- positive regulation of JUN kinase activity [IMP]
- positive regulation of NIK/NF-kappaB signaling [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of p38MAPK cascade [IMP]
- protein polyubiquitination [IDA]
- regulation of protein K63-linked ubiquitination [IDA]
- regulation of protein autoubiquitination [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SNX1
HsT17379, VPS5
sorting nexin 1
GO Process (6)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.
The tumor-suppressor sterile ? motif- and Src-homology 3-domain containing 1 (SASH1) has clinical relevance in colorectal carcinoma and is associated specifically with metachronous metastasis. We sought to identify the molecular mechanisms linking decreased SASH1 expression with distant metastasis formation.SASH1-deficient, SASH1-depleted, or SASH1-overexpressing HCT116 colon cancer cells were generated by the Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated 9-method, RNA interference, and transient ... [more]
Cell Mol Gastroenterol Hepatol Nov. 28, 2018; 7(1);33-53 [Pubmed: 30480076]
Throughput
- High Throughput
Curated By
- BioGRID