SASH1
Gene Ontology Biological Process
- positive regulation of JUN kinase activity [IMP]
- positive regulation of NIK/NF-kappaB signaling [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of p38MAPK cascade [IMP]
- protein polyubiquitination [IDA]
- regulation of protein K63-linked ubiquitination [IDA]
- regulation of protein autoubiquitination [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SPTBN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.
The tumor-suppressor sterile ? motif- and Src-homology 3-domain containing 1 (SASH1) has clinical relevance in colorectal carcinoma and is associated specifically with metachronous metastasis. We sought to identify the molecular mechanisms linking decreased SASH1 expression with distant metastasis formation.SASH1-deficient, SASH1-depleted, or SASH1-overexpressing HCT116 colon cancer cells were generated by the Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated 9-method, RNA interference, and transient ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SASH1 SPTBN1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID