BAIT
KRAS
C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2
Kirsten rat sarcoma viral oncogene homolog
GO Process (16)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein phosphorylation [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HGF
DFNB39, F-TCF, HGFB, HPTA, SF
hepatocyte growth factor (hepapoietin A; scatter factor)
GO Process (20)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell chemotaxis [IDA]
- cellular response to hepatocyte growth factor stimulus [IDA]
- epithelial to mesenchymal transition [TAS]
- hepatocyte growth factor receptor signaling pathway [IDA]
- mitotic nuclear division [NAS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of hydrogen peroxide-mediated programmed cell death [IDA]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive chemotaxis [IDA]
- positive regulation of DNA biosynthetic process [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of osteoblast differentiation [NAS]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of transcription from RNA polymerase II promoter [NAS]
- proteolysis [NAS]
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.
Activating mutations in the KRAS oncogene are highly prevalent in tumors, especially those of the colon, lung, and pancreas. To better understand the genetic dependencies that K-Ras mutant cells rely upon for their growth, we employed whole-genome CRISPR loss-of-function screens in two isogenic pairs of cell lines. Since loss of essential genes is uniformly toxic in CRISPR-based screens, we also ... [more]
Cell Rep Jul. 11, 2017; 20(2);427-438 [Pubmed: 28700943]
Throughput
- High Throughput
Additional Notes
- CRISPR screen analysis showed synthetic lethality with K-Ras mutant in DLD1 cells.
- Gene loss results in the selective reduction of K-Ras mutant cell growth.
- Synthetic lethality score > 1.0.
Curated By
- BioGRID