BAIT
TFE3
F830016E06Rik, Tcfe3, Tfe-3, bHLHe33, RP23-109E24.7
transcription factor E3
GO Process (6)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- humoral immune response [IMP]
- positive regulation of cell adhesion [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of osteoclast differentiation [IGI]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
ATP6V1A
AI647066, Atp6a1, Atp6a2, Atp6v1a1, VA68, VPP2
ATPase, H+ transporting, lysosomal V1 subunit A
GO Process (0)
GO Function (0)
GO Component (8)
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.
Self-renewal and differentiation of pluripotent murine embryonic stem cells (ESCs) is regulated by extrinsic signaling pathways. It is less clear whether cellular metabolism instructs developmental progression. In an unbiased genome-wide CRISPR/Cas9 screen, we identified components of a conserved amino-acid-sensing pathway as critical drivers of ESC differentiation. Functional analysis revealed that lysosome activity, the Ragulator protein complex, and the tumor-suppressor protein ... [more]
Cell Stem Cell Dec. 07, 2018; 24(2);257-270.e8 [Pubmed: 30595499]
Throughput
- High Throughput
Curated By
- BioGRID