BAIT
TFE3
F830016E06Rik, Tcfe3, Tfe-3, bHLHe33, RP23-109E24.7
transcription factor E3
GO Process (6)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- humoral immune response [IMP]
- positive regulation of cell adhesion [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of osteoclast differentiation [IGI]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
VIM
RP23-185P20.1
vimentin
GO Process (11)
GO Function (12)
GO Component (16)
Gene Ontology Biological Process
- Bergmann glial cell differentiation [IMP]
- SMAD protein signal transduction [IDA]
- astrocyte development [IGI]
- intermediate filament organization [IGI]
- intermediate filament-based process [IMP]
- lens fiber cell development [IDA]
- negative regulation of neuron projection development [IGI]
- positive regulation of gene expression [IMP]
- positive regulation of glial cell proliferation [ISO]
- regulation of Schwann cell migration [ISO]
- regulation of axonogenesis [ISO]
Gene Ontology Molecular Function- double-stranded RNA binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- scaffold protein binding [ISO]
- structural constituent of cytoskeleton [ISO]
- structural constituent of eye lens [IDA]
- structural molecule activity [IMP]
- double-stranded RNA binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- scaffold protein binding [ISO]
- structural constituent of cytoskeleton [ISO]
- structural constituent of eye lens [IDA]
- structural molecule activity [IMP]
Gene Ontology Cellular Component
- axon [ISO]
- cell body [ISO]
- cell leading edge [IDA]
- cell projection [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytoskeleton [ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intermediate filament [IDA, ISO]
- intermediate filament cytoskeleton [ISO]
- neuron projection [IDA]
- perinuclear region of cytoplasm [ISO]
- peroxisome [ISO]
- plasma membrane [IDA, ISO]
- type III intermediate filament [TAS]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.
Self-renewal and differentiation of pluripotent murine embryonic stem cells (ESCs) is regulated by extrinsic signaling pathways. It is less clear whether cellular metabolism instructs developmental progression. In an unbiased genome-wide CRISPR/Cas9 screen, we identified components of a conserved amino-acid-sensing pathway as critical drivers of ESC differentiation. Functional analysis revealed that lysosome activity, the Ragulator protein complex, and the tumor-suppressor protein ... [more]
Cell Stem Cell Dec. 07, 2018; 24(2);257-270.e8 [Pubmed: 30595499]
Throughput
- High Throughput
Curated By
- BioGRID