BAIT
TFE3
F830016E06Rik, Tcfe3, Tfe-3, bHLHe33, RP23-109E24.7
transcription factor E3
GO Process (6)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- humoral immune response [IMP]
- positive regulation of cell adhesion [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of osteoclast differentiation [IGI]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
ALS2
3222402C23Rik, 9430073A21Rik, Als2cr6, Alsin, mKIAA1563
amyotrophic lateral sclerosis 2 (juvenile)
GO Process (21)
GO Function (11)
GO Component (20)
Gene Ontology Biological Process
- Rac protein signal transduction [ISO]
- axonogenesis [ISO]
- behavioral fear response [IMP]
- cell death [ISO]
- endosomal transport [IMP]
- endosome organization [ISO]
- locomotory behavior [IMP]
- lysosomal transport [ISO]
- neuromuscular junction development [IMP]
- neuron projection morphogenesis [ISO]
- positive regulation of Rab GTPase activity [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein homooligomerization [ISO]
- protein localization [IMP]
- receptor recycling [IMP]
- regulation of Rab GTPase activity [IDA]
- response to oxidative stress [IMP]
- synaptic transmission, glutamatergic [IMP]
- vesicle organization [IDA]
Gene Ontology Molecular Function- Rab GTPase activator activity [ISO]
- Rab GTPase binding [ISO]
- Rab guanyl-nucleotide exchange factor activity [ISO]
- Rac GTPase activator activity [ISO]
- Rac GTPase binding [ISO]
- Rac guanyl-nucleotide exchange factor activity [ISO]
- guanyl-nucleotide exchange factor activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activator activity [ISO]
- Rab GTPase activator activity [ISO]
- Rab GTPase binding [ISO]
- Rab guanyl-nucleotide exchange factor activity [ISO]
- Rac GTPase activator activity [ISO]
- Rac GTPase binding [ISO]
- Rac guanyl-nucleotide exchange factor activity [ISO]
- guanyl-nucleotide exchange factor activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activator activity [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- cell [IMP]
- centrosome [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [ISO]
- dendritic spine [IDA]
- early endosome [ISO]
- growth cone [ISO]
- intracellular [IMP]
- intracellular membrane-bounded organelle [ISO]
- lamellipodium [IDA]
- membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- postsynaptic density [IDA]
- protein complex [ISO]
- ruffle [IDA]
- vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.
Self-renewal and differentiation of pluripotent murine embryonic stem cells (ESCs) is regulated by extrinsic signaling pathways. It is less clear whether cellular metabolism instructs developmental progression. In an unbiased genome-wide CRISPR/Cas9 screen, we identified components of a conserved amino-acid-sensing pathway as critical drivers of ESC differentiation. Functional analysis revealed that lysosome activity, the Ragulator protein complex, and the tumor-suppressor protein ... [more]
Cell Stem Cell Dec. 07, 2018; 24(2);257-270.e8 [Pubmed: 30595499]
Throughput
- High Throughput
Curated By
- BioGRID