PREY
MLLT11
AF1Q, RP11-316M1.10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
GO Process (6)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
- extrinsic apoptotic signaling pathway [IDA]
- intrinsic apoptotic signaling pathway [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of mitochondrial depolarization [IDA]
- positive regulation of release of cytochrome c from mitochondria [IDA]
- positive regulation of transcription, DNA-templated [IDA]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
The human cytoplasmic dynein interactome reveals novel activators of motility.
In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends. To understand how a single motor achieves cargo specificity, we identified the human dynein interactome by attaching a promiscuous biotin ligase ('BioID') to seven components of the dynein machinery, including a subunit of the essential cofactor dynactin. ... [more]
Elife Dec. 18, 2016; 6(); [Pubmed: 28718761]
Throughput
- High Throughput
Curated By
- BioGRID