BAIT
MTNR1A
MEL-1A-R, MT1
melatonin receptor 1A
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ADRBK1
Adrbk-1, Bark-1, GRK2, beta ARK, betaARK1
adrenergic receptor kinase, beta 1
GO Process (17)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO]
- cardiac muscle contraction [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway [IGI, IMP, ISO]
- follicle-stimulating hormone signaling pathway [ISO]
- heart development [IMP]
- negative regulation of G-protein coupled receptor protein signaling pathway [ISO]
- negative regulation of striated muscle contraction [ISO]
- negative regulation of the force of heart contraction by chemical signal [ISO]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of catecholamine secretion [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- receptor internalization [ISO]
- regulation of the force of heart contraction [IGI]
- response to organic cyclic compound [ISO]
- response to oxidative stress [ISO]
- tachykinin receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors.
G protein-coupled receptors (GPCRs) constitute the largest family of membrane receptors and are major drug targets. Recent progress has shown that GPCRs are part of large protein complexes that regulate their activity. We present here a generic approach for identification of these complexes that is based on the use of receptor subdomains and that overcomes the limitations of currently used ... [more]
Mol. Cell Proteomics Aug. 01, 2008; 7(8);1556-69 [Pubmed: 18448421]
Throughput
- Low Throughput
Curated By
- BioGRID