BAIT
MTNR1B
FGQTL2, MEL-1B-R, MT2
melatonin receptor 1B
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LCK
Hck-3, Lsk, Lskt, p56, p56Lck, RP23-209C6.8
lymphocyte protein tyrosine kinase
GO Process (27)
GO Function (17)
GO Component (11)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- T cell differentiation [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- cell surface receptor signaling pathway [IDA]
- cellular response to peptide hormone stimulus [IBA]
- dephosphorylation [ISO]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of T cell activation [ISO]
- positive regulation of T cell receptor signaling pathway [IBA]
- positive regulation of gamma-delta T cell differentiation [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- positive regulation of uterine smooth muscle contraction [ISO]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [IDA, ISO]
- regulation of T cell receptor signaling pathway [IDA]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- release of sequestered calcium ion into cytosol [IDA]
- response to drug [ISO]
- response to hydrogen peroxide [ISO]
- response to mechanical stimulus [ISO]
- response to metal ion [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- ATPase binding [ISO]
- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- SH2 domain binding [ISO]
- antigen binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [IBA]
- ATPase binding [ISO]
- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- SH2 domain binding [ISO]
- antigen binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [IBA]
Gene Ontology Cellular Component
Mus musculus
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors.
G protein-coupled receptors (GPCRs) constitute the largest family of membrane receptors and are major drug targets. Recent progress has shown that GPCRs are part of large protein complexes that regulate their activity. We present here a generic approach for identification of these complexes that is based on the use of receptor subdomains and that overcomes the limitations of currently used ... [more]
Mol. Cell Proteomics Aug. 01, 2008; 7(8);1556-69 [Pubmed: 18448421]
Throughput
- High Throughput
Curated By
- BioGRID