BAIT
ADORA2A
A2ar, ADENO, Adora2l1
adenosine A2a receptor
GO Process (44)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- adenosine receptor signaling pathway [IDA, ISO]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IMP, ISO]
- astrocyte activation [IMP]
- eating behavior [IMP, ISO]
- locomotory behavior [IMP, ISO]
- membrane depolarization [IMP]
- negative regulation of alpha-beta T cell activation [ISO]
- negative regulation of cell proliferation [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of inflammatory response [ISO]
- negative regulation of locomotion [IDA]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of vascular permeability [IMP]
- neuron projection morphogenesis [IDA, IMP]
- positive regulation of acetylcholine secretion, neurotransmission [IMP]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cAMP biosynthetic process [ISO]
- positive regulation of circadian sleep/wake cycle, sleep [IDA]
- positive regulation of glutamate secretion [IDA]
- positive regulation of protein secretion [IDA]
- positive regulation of renal sodium excretion [IDA, IMP]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of synaptic transmission, glutamatergic [IDA]
- positive regulation of urine volume [IMP]
- prepulse inhibition [IMP]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IDA]
- regulation of calcium ion transport [IMP]
- regulation of excitatory postsynaptic membrane potential [IDA]
- regulation of inhibitory postsynaptic membrane potential [ISO]
- regulation of mitochondrial membrane potential [IDA]
- regulation of norepinephrine secretion [IMP]
- regulation of synaptic plasticity [IDA]
- regulation of transcription, DNA-templated [IDA]
- response to alkaloid [IMP]
- response to amphetamine [ISO]
- response to caffeine [IDA]
- response to drug [IEP]
- synaptic transmission, cholinergic [IMP]
- synaptic transmission, dopaminergic [ISO]
- synaptic transmission, glutamatergic [IDA]
- vasodilation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- asymmetric synapse [IDA]
- axolemma [IDA]
- axon [IDA]
- dendrite [IDA]
- endomembrane system [IDA]
- integral component of plasma membrane [ISO]
- intermediate filament [IDA]
- membrane [IDA, ISO]
- neuronal cell body [IDA]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- postsynaptic membrane [IDA]
- presynaptic active zone [IDA]
- presynaptic membrane [IDA]
Rattus norvegicus
PREY
GRM5
mGluR5
glutamate receptor, metabotropic 5
GO Process (17)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IMP, ISO, ISS]
- activation of MAPKKK activity [IDA]
- cognition [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway [IDA]
- learning [ISO]
- locomotory behavior [ISO]
- negative regulation of locomotion [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [TAS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [TAS]
- positive regulation of long-term neuronal synaptic plasticity [IDA]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IDA, TAS]
- protein phosphorylation [IDA]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of synaptic transmission, glutamatergic [IBA]
- regulation of transcription, DNA-templated [IDA]
- synaptic transmission [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.
The physiological meaning of the coexpression of adenosine A2A receptors and group I metabotropic glutamate receptors in gamma- aminobutyric acid (GABA)ergic striatal neurons is intriguing. Here we provide in vitro and in vivo evidence for a synergism between adenosine and glutamate based on subtype 5 metabotropic glutamate (mGluR5) and adenosine A2A (A2AR) receptor/receptor interactions. Colocalization of A2AR and mGluR5 at ... [more]
Proc. Natl. Acad. Sci. U.S.A. Sep. 03, 2002; 99(18);11940-5 [Pubmed: 12189203]
Throughput
- Low Throughput
Curated By
- BioGRID