BAIT
C3
AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
complement component 3
GO Process (15)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- complement activation [IMP, TAS]
- complement activation, alternative pathway [TAS]
- immune response [TAS]
- innate immune response [TAS]
- positive regulation of G-protein coupled receptor protein signaling pathway [IDA]
- positive regulation of apoptotic cell clearance [IMP]
- positive regulation of glucose transport [IDA]
- positive regulation of lipid storage [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of complement activation [TAS]
- regulation of immune response [TAS]
- regulation of triglyceride biosynthetic process [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATG16L1
APG16L, ATG16A, ATG16L, IBD10, WDR30, hCG_1817841
autophagy related 16-like 1 (S. cerevisiae)
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents ? Cell Death via ATG16L1 Interaction and Autophagy Regulation.
We show here that human pancreatic islets highly express C3, which is both secreted and present in the cytosol. Within isolated human islets, C3 expression correlates with type 2 diabetes (T2D) donor status, HbA1c, and inflammation. Islet C3 expression is also upregulated in several rodent diabetes models. C3 interacts with ATG16L1, which is essential for autophagy. Autophagy relieves cellular stresses ... [more]
Cell Metab. Dec. 08, 2018; 29(1);202-210.e6 [Pubmed: 30293775]
Throughput
- Low Throughput
Curated By
- BioGRID