ATXN1
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- lung alveolus development [IGI]
- negative regulation of insulin-like growth factor receptor signaling pathway [IMP]
- negative regulation of phosphorylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- negative regulation of transcription, DNA-templated [ISO]
- nuclear export [ISO]
- positive regulation of glial cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of excitatory postsynaptic membrane potential [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATP1A1
Gene Ontology Biological Process
- ATP catabolic process [IMP]
- cellular potassium ion homeostasis [ISO]
- cellular response to mechanical stimulus [ISO]
- cellular response to steroid hormone stimulus [ISO]
- cellular sodium ion homeostasis [ISO]
- dephosphorylation [IMP]
- membrane hyperpolarization [ISO]
- membrane repolarization [ISO]
- negative regulation of glucocorticoid biosynthetic process [IMP]
- negative regulation of heart contraction [IMP]
- positive regulation of heart contraction [IMP]
- positive regulation of striated muscle contraction [IMP]
- potassium ion import [ISO]
- potassium ion transmembrane transport [IMP]
- potassium ion transport [ISO]
- regulation of blood pressure [IGI]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of sodium ion transport [ISO]
- regulation of the force of heart contraction [IMP]
- response to drug [IMP]
- response to glycoside [IGI]
- sodium ion export from cell [ISO]
- sodium ion transmembrane transport [IMP, ISO]
- sodium ion transport [ISO]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ankyrin binding [ISO]
- chaperone binding [ISO]
- phosphatase activity [IMP]
- phosphatidylinositol 3-kinase binding [ISO]
- potassium ion binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- sodium ion binding [ISO]
- sodium:potassium-exchanging ATPase activity [IDA, IMP, ISO]
- steroid hormone binding [ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ankyrin binding [ISO]
- chaperone binding [ISO]
- phosphatase activity [IMP]
- phosphatidylinositol 3-kinase binding [ISO]
- potassium ion binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- sodium ion binding [ISO]
- sodium:potassium-exchanging ATPase activity [IDA, IMP, ISO]
- steroid hormone binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- T-tubule [IDA, ISO]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- caveola [ISO]
- endoplasmic reticulum [ISO]
- endosome [ISO]
- extracellular vesicular exosome [ISO]
- intercalated disc [ISO]
- membrane [IDA, ISO]
- membrane raft [ISO]
- myelin sheath [IDA]
- neuronal postsynaptic density [IDA]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- sodium:potassium-exchanging ATPase complex [ISO]
- vesicle [ISO]
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.
Ataxin-1 mutation, arising from a polyglutamine (polyQ) tract expansion, is the underlying genetic cause of the late-onset neurodegenerative disease Spinocerebellar ataxia type 1 (SCA1). To identify protein partners of polyQ-ataxin-1 in neuronal cells under control or stress conditions, here we report our complementary proteomics strategies of proximity-dependent biotin identification (BioID) and affinity purification (via GFP-Trap pulldown) in Neuro-2a cells expressing ... [more]
Throughput
- High Throughput
Additional Notes
- ataxin-1[85Q]
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATXN1 ATP1A1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2622411 |
Curated By
- BioGRID