BAIT

SPAC824.04

WD repeat protein (predicted)
GO Process (2)
GO Function (0)
GO Component (3)
Schizosaccharomyces pombe (972h)
PREY

SSU72

SPAC3G9.04
phosphoric ester hydrolase Ssu72 (predicted)
GO Process (2)
GO Function (1)
GO Component (3)
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

RNA polymerase II CTD interactome with 3' processing and termination factors in fission yeast and its impact on phosphate homeostasis.

Sanchez AM, Shuman S, Schwer B

The carboxy-terminal domain (CTD) code encrypted within the Y1S2P3T4S5P6S7 heptad repeats of RNA polymerase II (Pol2) is deeply rooted in eukaryal biology. Key steps to deciphering the code are identifying the events in gene expression that are governed by individual "letters" and then defining a vocabulary of multiletter "words" and their meaning. Thr4 and Ser7 exert opposite effects on the ... [more]

Proc. Natl. Acad. Sci. U.S.A. Dec. 06, 2017; 115(45);E10652-E10661 [Pubmed: 30355770]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • Figure 6
  • ssu72-C13S

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SPAC824.04 SSU72
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Low-BioGRID
-
SPAC824.04 SSU72
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High-BioGRID
-
SSU72 SPAC824.04
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-18.4092BioGRID
523219
SSU72 SPAC824.04
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-8.6301BioGRID
762901

Curated By

  • BioGRID