BAIT
SLC8A1
AI852629, AV344025, D930008O12Rik, Ncx1
solute carrier family 8 (sodium/calcium exchanger), member 1
GO Process (38)
GO Function (6)
GO Component (17)
Gene Ontology Biological Process
- calcium ion export [IMP, ISO]
- calcium ion homeostasis [IMP]
- calcium ion import [IMP, ISO]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IDA, IMP]
- calcium ion transport into cytosol [IMP, ISO]
- cardiac muscle cell development [IMP]
- cardiac muscle contraction [IGI]
- cell communication by electrical coupling involved in cardiac conduction [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to cAMP [ISO]
- cellular response to caffeine [IMP]
- cellular response to reactive oxygen species [ISO]
- cellular sodium ion homeostasis [ISO]
- embryonic heart tube development [IMP]
- embryonic placenta development [IMP]
- heart morphogenesis [IGI]
- muscle fiber development [IGI]
- negative regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of fibroblast migration [ISO]
- positive regulation of the force of heart contraction [ISO]
- post-embryonic development [IGI]
- regulation of calcium ion transport [ISO]
- regulation of cardiac muscle cell membrane potential [TAS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISO]
- regulation of heart rate [IMP]
- regulation of sodium ion transport [ISO]
- regulation of the force of heart contraction [IMP]
- relaxation of smooth muscle [IMP]
- response to ATP [ISO]
- response to hypoxia [ISO]
- response to muscle stretch [ISO]
- sodium ion export [IMP, ISO]
- sodium ion import [IMP, ISO]
- sodium ion transmembrane transport [IDA]
- sodium ion transport [IDA, ISO]
- vascular smooth muscle contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [IDA, ISO]
- Z disc [ISO]
- basolateral plasma membrane [IDA]
- cell [IMP]
- cell projection [ISO]
- cytosol [IMP]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- integral component of membrane [TAS]
- integral component of plasma membrane [ISO]
- intercalated disc [ISO]
- intracellular [IMP]
- membrane [IDA]
- microtubule [ISO]
- mitochondrion [ISO]
- plasma membrane [IDA, ISO]
- sarcolemma [IDA, ISO]
Mus musculus
PREY
GPX1
GSHPx, GSHPx-1
glutathione peroxidase 1
GO Process (52)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- UV protection [ISO]
- aging [IEP]
- angiogenesis involved in wound healing [ISO]
- apoptotic process [ISO]
- blood vessel endothelial cell migration [ISO]
- cell proliferation [ISO]
- cell redox homeostasis [ISO]
- endothelial cell development [ISO]
- fat cell differentiation [ISO]
- glutathione metabolic process [IDA, ISO]
- heart contraction [ISO]
- hydrogen peroxide catabolic process [IDA, ISO]
- interaction with symbiont [ISO]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- lipid metabolic process [ISO]
- myoblast proliferation [ISO]
- myotube differentiation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- negative regulation of inflammatory response to antigenic stimulus [ISO]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- positive regulation of protein kinase B signaling [ISO]
- protein oxidation [ISO]
- regulation of gene expression, epigenetic [ISO]
- regulation of mammary gland epithelial cell proliferation [ISO]
- regulation of neuron apoptotic process [ISO]
- regulation of proteasomal protein catabolic process [ISO]
- response to estradiol [IEP]
- response to folic acid [IEP]
- response to gamma radiation [ISO]
- response to glucose [IEP]
- response to hormone [IEP]
- response to hydrogen peroxide [ISO]
- response to hydroperoxide [ISO]
- response to lipid hydroperoxide [IMP]
- response to nicotine [IEP]
- response to organic cyclic compound [IEP]
- response to oxidative stress [ISO, TAS]
- response to reactive oxygen species [ISO]
- response to selenium ion [IEP, ISO]
- response to symbiotic bacterium [ISO]
- response to toxic substance [ISO]
- response to wounding [ISO]
- response to xenobiotic stimulus [ISO]
- sensory perception of sound [ISO]
- skeletal muscle fiber development [ISO]
- skeletal muscle tissue regeneration [ISO]
- temperature homeostasis [ISO]
- triglyceride metabolic process [ISO]
- vasodilation [ISO]
Gene Ontology Molecular Function
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1).
The sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1) is an antiporter membrane protein encoded by the SLC8A1 gene. In the heart, it maintains cytosolic Ca2+ homeostasis, serving as the primary mechanism for Ca2+ extrusion during relaxation. Dysregulation of NCX1 is observed in end-stage human heart failure. In this study, we used affinity purification coupled with MS in rat left ... [more]
Proteomics Sep. 01, 2017; 17(17-18); [Pubmed: 28755400]
Throughput
- High Throughput
Curated By
- BioGRID