BAIT
SLC8A1
AI852629, AV344025, D930008O12Rik, Ncx1
solute carrier family 8 (sodium/calcium exchanger), member 1
GO Process (38)
GO Function (6)
GO Component (17)
Gene Ontology Biological Process
- calcium ion export [IMP, ISO]
- calcium ion homeostasis [IMP]
- calcium ion import [IMP, ISO]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IDA, IMP]
- calcium ion transport into cytosol [IMP, ISO]
- cardiac muscle cell development [IMP]
- cardiac muscle contraction [IGI]
- cell communication by electrical coupling involved in cardiac conduction [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to cAMP [ISO]
- cellular response to caffeine [IMP]
- cellular response to reactive oxygen species [ISO]
- cellular sodium ion homeostasis [ISO]
- embryonic heart tube development [IMP]
- embryonic placenta development [IMP]
- heart morphogenesis [IGI]
- muscle fiber development [IGI]
- negative regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of fibroblast migration [ISO]
- positive regulation of the force of heart contraction [ISO]
- post-embryonic development [IGI]
- regulation of calcium ion transport [ISO]
- regulation of cardiac muscle cell membrane potential [TAS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISO]
- regulation of heart rate [IMP]
- regulation of sodium ion transport [ISO]
- regulation of the force of heart contraction [IMP]
- relaxation of smooth muscle [IMP]
- response to ATP [ISO]
- response to hypoxia [ISO]
- response to muscle stretch [ISO]
- sodium ion export [IMP, ISO]
- sodium ion import [IMP, ISO]
- sodium ion transmembrane transport [IDA]
- sodium ion transport [IDA, ISO]
- vascular smooth muscle contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [IDA, ISO]
- Z disc [ISO]
- basolateral plasma membrane [IDA]
- cell [IMP]
- cell projection [ISO]
- cytosol [IMP]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- integral component of membrane [TAS]
- integral component of plasma membrane [ISO]
- intercalated disc [ISO]
- intracellular [IMP]
- membrane [IDA]
- microtubule [ISO]
- mitochondrion [ISO]
- plasma membrane [IDA, ISO]
- sarcolemma [IDA, ISO]
Mus musculus
PREY
HSPA1A
HSP72, Hsp70-1, Hspa1, Hspa1b
heat shock 70kD protein 1A
GO Process (24)
GO Function (15)
GO Component (22)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA repair [ISO]
- binding of sperm to zona pellucida [ISO]
- cellular heat acclimation [ISO]
- cellular response to heat [ISO]
- defense response [IDA]
- mRNA catabolic process [ISO, ISS]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell growth [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of inclusion body assembly [ISO]
- negative regulation of myeloid cell apoptotic process [IDA]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of vasoconstriction [IMP]
- positive regulation of T cell mediated cytotoxicity [IDA]
- positive regulation of erythrocyte differentiation [ISO]
- protein refolding [ISO]
- regulation of cell death [ISO]
- response to heat [ISO]
- response to unfolded protein [IMP, ISO, ISS]
- telomere maintenance [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [ISO]
- G-protein coupled receptor binding [ISO]
- NF-kappaB binding [IPI]
- double-stranded RNA binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [IPI]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding involved in protein folding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [ISO]
- G-protein coupled receptor binding [ISO]
- NF-kappaB binding [IPI]
- double-stranded RNA binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [IPI]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding involved in protein folding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- aggresome [ISO]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- blood microparticle [ISO]
- cell body [ISO]
- centriole [ISO]
- cytoplasm [ISO, ISS]
- cytosol [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- inclusion body [ISO]
- intracellular [ISO]
- mitochondrion [ISO]
- nuclear speck [ISO, ISS]
- nucleus [IDA, ISO, ISS]
- perinuclear region of cytoplasm [ISO, ISS]
- protein complex [IDA]
- ribonucleoprotein complex [ISO]
- ubiquitin ligase complex [ISO]
- vesicle [ISO]
- zona pellucida receptor complex [ISO]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1).
The sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1) is an antiporter membrane protein encoded by the SLC8A1 gene. In the heart, it maintains cytosolic Ca2+ homeostasis, serving as the primary mechanism for Ca2+ extrusion during relaxation. Dysregulation of NCX1 is observed in end-stage human heart failure. In this study, we used affinity purification coupled with MS in rat left ... [more]
Proteomics Sep. 01, 2017; 17(17-18); [Pubmed: 28755400]
Throughput
- High Throughput
Curated By
- BioGRID