BAIT
SLC8A1
Ncx, Ncx1
solute carrier family 8 (sodium/calcium exchanger), member 1
GO Process (44)
GO Function (5)
GO Component (16)
Gene Ontology Biological Process
- calcium ion export [IDA, ISO]
- calcium ion homeostasis [ISO]
- calcium ion import [IDA, ISO]
- calcium ion transmembrane transport [IDA, IMP, ISO]
- calcium ion transport [ISO, TAS]
- calcium ion transport into cytosol [IDA, ISO]
- cardiac muscle cell development [ISO]
- cardiac muscle contraction [ISO]
- cell communication by electrical coupling involved in cardiac conduction [IDA]
- cellular calcium ion homeostasis [IMP]
- cellular response to cAMP [IDA]
- cellular response to caffeine [ISO]
- cellular response to hypoxia [IEP]
- cellular response to reactive oxygen species [IDA, ISO]
- cellular sodium ion homeostasis [ISO]
- embryonic heart tube development [ISO]
- embryonic placenta development [ISO]
- heart morphogenesis [ISO]
- muscle fiber development [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of fibroblast migration [IMP]
- positive regulation of the force of heart contraction [ISO]
- post-embryonic development [ISO]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IDA]
- regulation of heart rate [ISO]
- regulation of sodium ion transport [IMP]
- regulation of the force of heart contraction [ISO]
- relaxation of smooth muscle [ISO]
- response to ATP [IDA]
- response to drug [IEP]
- response to glucose [IEP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IDA]
- response to immobilization stress [IEP]
- response to muscle stretch [ISO]
- response to nutrient [IEP]
- sodium ion export [IDA, ISO]
- sodium ion import [IDA, ISO]
- sodium ion transmembrane transport [ISO]
- sodium ion transport [IDA, ISO]
- telencephalon development [IEP]
- vascular smooth muscle contraction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [IDA, ISO, TAS]
- Z disc [IDA]
- basolateral plasma membrane [ISO]
- cell [ISO]
- cell projection [IDA]
- cytosol [ISO]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- integral component of plasma membrane [ISO]
- intercalated disc [IDA]
- intracellular [ISO]
- membrane [ISO]
- microtubule [IDA]
- mitochondrion [IDA]
- plasma membrane [IDA, ISO]
- sarcolemma [IDA, ISO]
Rattus norvegicus
PREY
STK39
Spak
serine threonine kinase 39
GO Process (14)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- intracellular signal transduction [IBA, ISO]
- negative regulation of potassium ion transmembrane transport [ISO]
- negative regulation of potassium ion transmembrane transporter activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of rubidium ion transmembrane transporter activity [ISO]
- negative regulation of rubidium ion transport [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of potassium ion transport [IMP]
- protein phosphorylation [IDA]
- regulation of blood pressure [ISO]
- regulation of inflammatory response [ISO]
- regulation of ion homeostasis [ISO]
- signal transduction by phosphorylation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1).
The sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1) is an antiporter membrane protein encoded by the SLC8A1 gene. In the heart, it maintains cytosolic Ca2+ homeostasis, serving as the primary mechanism for Ca2+ extrusion during relaxation. Dysregulation of NCX1 is observed in end-stage human heart failure. In this study, we used affinity purification coupled with MS in rat left ... [more]
Proteomics Sep. 01, 2017; 17(17-18); [Pubmed: 28755400]
Throughput
- High Throughput
Curated By
- BioGRID