BAIT
SQSTM1
A170, OSF-6, Osi, STAP, STONE14, p62, RP23-319B15.3
sequestosome 1
GO Process (7)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- autophagy [ISO]
- positive regulation of macroautophagy [IBA, ISO]
- positive regulation of protein phosphorylation [ISO]
- protein heterooligomerization [ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of nucleic acid-templated transcription [TAS]
- ubiquitin-dependent protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SLC25A3
5730556H19Rik, PTP, Phc
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
GO Process (0)
GO Function (1)
GO Component (5)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy.
Autophagy maintains hematopoietic stem cell integrity and prevents malignant transformation. In addition to bulk degradation, selective autophagy serves as an intracellular quality control mechanism and requires autophagy receptors, such as p62 (SQSTM1), to specifically bridge the ubiquitinated cargos into autophagosomes. Here, we investigated the function of p62 in acute myeloid leukemia (AML) in vitro and in murine in vivo models ... [more]
Blood Dec. 10, 2018; 133(2);168-179 [Pubmed: 30498063]
Throughput
- High Throughput
Curated By
- BioGRID