KCNA2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CNTNAP2
Gene Ontology Biological Process
- adult behavior [IMP]
- brain development [TAS]
- cellular protein localization [ISS]
- cerebral cortex development [IEP]
- clustering of voltage-gated potassium channels [ISS]
- learning [IMP]
- limbic system development [IEP]
- neuron projection development [ISS]
- neuron recognition [NAS]
- protein localization to juxtaparanode region of axon [ISS]
- social behavior [IMP]
- striatum development [IEP]
- superior temporal gyrus development [IEP]
- thalamus development [IEP]
- transmission of nerve impulse [NAS]
- vocalization behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Clustering of neuronal potassium channels is independent of their interaction with PSD-95.
Voltage-dependent potassium channels regulate membrane excitability and cell-cell communication in the mammalian nervous system, and are found highly localized at distinct neuronal subcellular sites. Kv1 (mammalian Shaker family) potassium channels and the neurexin Caspr2, both of which contain COOH-terminal PDZ domain binding peptide motifs, are found colocalized at high density at juxtaparanodes flanking nodes of Ranvier of myelinated axons. The ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID