SUMO1
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular protein metabolic process [TAS]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of DNA binding [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- palate development [ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein complex assembly [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of protein localization [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HIPK2
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [ISO]
- SMAD protein signal transduction [ISO]
- adult locomotory behavior [IMP]
- adult walking behavior [IMP]
- anterior/posterior pattern specification [IGI]
- embryonic camera-type eye morphogenesis [IMP]
- embryonic retina morphogenesis in camera-type eye [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IGI]
- iris morphogenesis [IMP]
- lens induction in camera-type eye [IMP]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of nucleic acid-templated transcription [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neuron differentiation [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of DNA binding [IDA]
- positive regulation of JNK cascade [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell proliferation [IGI]
- positive regulation of protein binding [IDA]
- positive regulation of protein phosphorylation [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- protein phosphorylation [IDA, ISA, ISO]
- retina layer formation [IMP]
- smoothened signaling pathway [IGI]
- transforming growth factor beta receptor signaling pathway [IMP]
- voluntary musculoskeletal movement [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IMP]
- SMAD binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA, ISO]
- protein serine/threonine kinase activity [IDA, ISA]
- transcription corepressor activity [IDA, ISO]
- virion binding [ISO]
- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IMP]
- SMAD binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA, ISO]
- protein serine/threonine kinase activity [IDA, ISA]
- transcription corepressor activity [IDA, ISO]
- virion binding [ISO]
Gene Ontology Cellular Component
- PML body [ISO, TAS]
- cytoplasm [IDA]
- intracellular [IGI]
- nuclear body [ISO]
- nucleus [IDA, ISO]
- protein complex [IMP]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Functional impairment of the HIPK2 small ubiquitin-like modifier (SUMO)-interacting motif in acute myeloid leukemia.
Covalent conjugations of the SUMO-1 moiety on a target protein play important roles in the regulation of cellular protein function. SUMO-conjugation of PML is a regulatory step for PML nuclear body (PML-NB) formation, and HIPK2 is SUMO-conjugated and recruited into the PML-NBs. Although HIPK2 mutations (R861W and N951I) were found in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients, ... [more]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SUMO1 HIPK2 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | 2623491 |
Curated By
- BioGRID