UBE2I
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HIPK2
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [ISO]
- SMAD protein signal transduction [ISO]
- adult locomotory behavior [IMP]
- adult walking behavior [IMP]
- anterior/posterior pattern specification [IGI]
- embryonic camera-type eye morphogenesis [IMP]
- embryonic retina morphogenesis in camera-type eye [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IGI]
- iris morphogenesis [IMP]
- lens induction in camera-type eye [IMP]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of nucleic acid-templated transcription [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neuron differentiation [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of DNA binding [IDA]
- positive regulation of JNK cascade [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell proliferation [IGI]
- positive regulation of protein binding [IDA]
- positive regulation of protein phosphorylation [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- protein phosphorylation [IDA, ISA, ISO]
- retina layer formation [IMP]
- smoothened signaling pathway [IGI]
- transforming growth factor beta receptor signaling pathway [IMP]
- voluntary musculoskeletal movement [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IMP]
- SMAD binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA, ISO]
- protein serine/threonine kinase activity [IDA, ISA]
- transcription corepressor activity [IDA, ISO]
- virion binding [ISO]
- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IMP]
- SMAD binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA, ISO]
- protein serine/threonine kinase activity [IDA, ISA]
- transcription corepressor activity [IDA, ISO]
- virion binding [ISO]
Gene Ontology Cellular Component
- PML body [ISO, TAS]
- cytoplasm [IDA]
- intracellular [IGI]
- nuclear body [ISO]
- nucleus [IDA, ISO]
- protein complex [IMP]
Biochemical Activity (Sumoylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Functional impairment of the HIPK2 small ubiquitin-like modifier (SUMO)-interacting motif in acute myeloid leukemia.
Covalent conjugations of the SUMO-1 moiety on a target protein play important roles in the regulation of cellular protein function. SUMO-conjugation of PML is a regulatory step for PML nuclear body (PML-NB) formation, and HIPK2 is SUMO-conjugated and recruited into the PML-NBs. Although HIPK2 mutations (R861W and N951I) were found in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID