BAIT
ATXN3
AT3, ATX3, JOS, MJD, MJD1, SCA3, RP11-529H20.5
ataxin 3
GO Process (15)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- cellular response to heat [ISS]
- cellular response to misfolded protein [ISS]
- intermediate filament cytoskeleton organization [IMP]
- microtubule cytoskeleton organization [IMP]
- misfolded or incompletely synthesized protein catabolic process [ISS]
- monoubiquitinated protein deubiquitination [ISS]
- nervous system development [TAS]
- nucleotide-excision repair [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISS]
- protein K48-linked deubiquitination [IDA]
- protein K63-linked deubiquitination [IDA]
- regulation of cell-substrate adhesion [IMP]
- synaptic transmission [TAS]
- ubiquitin-dependent protein catabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACACA
ACAC, ACACAD, ACC, ACC1, ACCA
acetyl-CoA carboxylase alpha
GO Process (13)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- acetyl-CoA metabolic process [ISS]
- biotin metabolic process [TAS]
- carnitine shuttle [TAS]
- cellular lipid metabolic process [TAS]
- energy reserve metabolic process [TAS]
- fatty acid biosynthetic process [ISS]
- long-chain fatty-acyl-CoA biosynthetic process [TAS]
- positive regulation of cellular metabolic process [TAS]
- protein homotetramerization [ISS]
- small molecule metabolic process [TAS]
- triglyceride biosynthetic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Physiological and pathophysiological characteristics of ataxin-3 isoforms.
Ataxin-3 is a deubiquitinating enzyme and the affected protein in the neurodegenerative disorder Machado-Joseph disease (MJD). The ATXN3 gene is alternatively spliced, resulting in protein isoforms that differ in the number of ubiquitin-interacting motifs. Additionally, nonsynonymous SNPs in ATXN3 cause amino acid changes in ataxin-3, and one of these polymorphisms introduces a premature stop codon in one isoform. Here, we ... [more]
J. Biol. Chem. Dec. 11, 2018; 294(2);644-661 [Pubmed: 30455355]
Throughput
- High Throughput
Curated By
- BioGRID