BAIT
CHRM1
HM1, M1, M1R
cholinergic receptor, muscarinic 1
GO Process (10)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway [TAS]
- cell proliferation [TAS]
- cellular protein modification process [TAS]
- nervous system development [TAS]
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of ion transport [IGI]
- protein kinase C-activating G-protein coupled receptor signaling pathway [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RGS7
RP11-80B9.3
regulator of G-protein signaling 7
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.
Regulators of G protein signaling (RGS) make up a diverse family primarily known as GTPase-activating proteins (GAPs) for heterotrimeric G proteins. In addition to the RGS domain, which is responsible for GAP activity, most RGS proteins contain other distinct structural motifs. For example, members of the R7 family of RGS proteins contain a DEP, GGL, and novel DHEX domain and ... [more]
Biochemistry Mar. 17, 2009; 48(10);2282-9 [Pubmed: 19182865]
Throughput
- Low Throughput
Curated By
- BioGRID