KCNB1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VAPA
Gene Ontology Biological Process
- COPII-coated vesicle budding [ISO]
- ER to Golgi vesicle-mediated transport [ISO]
- cell death [IMP, ISO]
- endoplasmic reticulum organization [ISO]
- negative regulation by host of viral genome replication [ISO]
- neuron projection development [IMP, ISO]
- positive regulation by host of viral genome replication [ISO]
- positive regulation by host of viral release from host cell [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- protein folding in endoplasmic reticulum [ISO]
- protein localization to endoplasmic reticulum [ISO, ISS]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Kv2 potassium channels form endoplasmic reticulum/plasma membrane junctions via interaction with VAPA and VAPB.
Kv2.1 exhibits two distinct forms of localization patterns on the neuronal plasma membrane: One population is freely diffusive and regulates electrical activity via voltage-dependent K+ conductance while a second one localizes to micrometer-sized clusters that contain densely packed, but nonconducting, channels. We have previously established that these clusters represent endoplasmic reticulum/plasma membrane (ER/PM) junctions that function as membrane trafficking hubs ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID