ATP2A2
Gene Ontology Biological Process
- blood coagulation [TAS]
- calcium ion import into sarcoplasmic reticulum [IC, ISS]
- calcium ion transmembrane transport [IDA]
- calcium ion transport from cytosol to endoplasmic reticulum [IDA]
- cell adhesion [TAS]
- cellular calcium ion homeostasis [IDA]
- endoplasmic reticulum calcium ion homeostasis [IDA]
- epidermis development [TAS]
- ion transmembrane transport [TAS]
- positive regulation of endoplasmic reticulum calcium ion concentration [IDA]
- positive regulation of heart rate [TAS]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [ISS]
- regulation of cardiac muscle cell membrane potential [IC, ISS, TAS]
- regulation of cardiac muscle contraction by calcium ion signaling [IDA]
- relaxation of cardiac muscle [IDA]
- sarcoplasmic reticulum calcium ion transport [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcium ion-transporting ATPase complex [IDA]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [IDA, TAS]
- integral component of plasma membrane [TAS]
- intercalated disc [IDA]
- longitudinal sarcoplasmic reticulum [IDA]
- membrane [IDA]
- platelet dense tubular network membrane [TAS]
- sarcoplasmic reticulum [IDA]
- sarcoplasmic reticulum membrane [IC, TAS]
VCP
Gene Ontology Biological Process
- DNA repair [NAS]
- ER-associated ubiquitin-dependent protein catabolic process [IDA, IMP, TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- cellular response to DNA damage stimulus [IDA]
- double-strand break repair [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- establishment of protein localization [TAS]
- positive regulation of Lys63-specific deubiquitinase activity [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein K63-linked deubiquitination [IDA]
- positive regulation of protein catabolic process [IDA]
- positive regulation of protein complex assembly [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [NAS]
- protein N-linked glycosylation via asparagine [IMP]
- protein ubiquitination [IDA, NAS]
- regulation of apoptotic process [TAS]
- retrograde protein transport, ER to cytosol [IDA]
- translesion synthesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Hrd1p ubiquitin ligase complex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [IDA]
- extracellular vesicular exosome [IDA]
- intracellular membrane-bounded organelle [ISS]
- lipid particle [IDA]
- nucleoplasm [IDA]
- nucleus [IDA, TAS]
- perinuclear region of cytoplasm [IDA]
- proteasome complex [IDA]
- site of double-strand break [IDA]
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.
Mitochondrial protein (MP) assemblies undergo alterations during neurogenesis, a complex process vital in brain homeostasis and disease. Yet which MP assemblies remodel during differentiation remains unclear. Here, using mass spectrometry-based co-fractionation profiles and phosphoproteomics, we generated mitochondrial interaction maps of human pluripotent embryonal carcinoma stem cells and differentiated neuronal-like cells, which presented as two discrete cell populations by single-cell RNA ... [more]
Quantitative Score
- 1.724622175 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Protein pairs with Sigma LLS score >= 1.45 derived from Ntera2 embryonic carcinoma stem cells (ECSC)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
VCP ATP2A2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID