BAIT
NDUFS3
CI-30
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
GO Process (8)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cellular metabolic process [TAS]
- mitochondrial electron transport, NADH to ubiquinone [NAS]
- negative regulation of cell growth [IMP]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- reactive oxygen species metabolic process [IMP]
- respiratory electron transport chain [TAS]
- small molecule metabolic process [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ASPH
AAH, BAH, CASQ2BP1, FDLAB, HAAH, JCTN, junctin
aspartate beta-hydroxylase
GO Process (17)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity [IDA]
- activation of store-operated calcium channel activity [IDA]
- calcium ion transmembrane transport [IDA]
- cellular response to calcium ion [IDA]
- detection of calcium ion [TAS]
- muscle contraction [TAS]
- positive regulation of calcium ion transport into cytosol [IDA]
- positive regulation of intracellular protein transport [IDA]
- positive regulation of proteolysis [IDA]
- positive regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISS, TAS]
- regulation of cell communication by electrical coupling [TAS]
- regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [TAS]
- regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- response to ATP [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcium channel complex [TAS]
- cortical endoplasmic reticulum [IDA]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [NAS]
- integral component of endoplasmic reticulum membrane [IDA]
- junctional sarcoplasmic reticulum membrane [TAS]
- plasma membrane [IDA]
- sarcoplasmic reticulum lumen [TAS]
- sarcoplasmic reticulum membrane [TAS]
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.
Mitochondrial protein (MP) assemblies undergo alterations during neurogenesis, a complex process vital in brain homeostasis and disease. Yet which MP assemblies remodel during differentiation remains unclear. Here, using mass spectrometry-based co-fractionation profiles and phosphoproteomics, we generated mitochondrial interaction maps of human pluripotent embryonal carcinoma stem cells and differentiated neuronal-like cells, which presented as two discrete cell populations by single-cell RNA ... [more]
iScience Sep. 27, 2019; 19();1114-1132 [Pubmed: 31536960]
Quantitative Score
- 1.720923854 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Protein pairs with Sigma LLS score >= 1.45 derived from Ntera2 embryonic carcinoma stem cells (ECSC)
Curated By
- BioGRID