BAIT
UQCRC2
MC3DN5, QCR2, UQCR2
ubiquinol-cytochrome c reductase core protein II
GO Process (5)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRDX3
AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III
peroxiredoxin 3
GO Process (15)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- cellular response to oxidative stress [IDA]
- cellular response to reactive oxygen species [IMP]
- hydrogen peroxide catabolic process [IGI, IMP]
- mitochondrion organization [IMP]
- myeloid cell differentiation [ISS]
- negative regulation of apoptotic process [IDA, IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of kinase activity [IDA]
- peptidyl-cysteine oxidation [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of cell proliferation [IDA]
- regulation of mitochondrial membrane potential [IMP]
- response to hydrogen peroxide [IDA]
- response to lipopolysaccharide [ISS]
- response to oxidative stress [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.
Mitochondrial protein (MP) assemblies undergo alterations during neurogenesis, a complex process vital in brain homeostasis and disease. Yet which MP assemblies remodel during differentiation remains unclear. Here, using mass spectrometry-based co-fractionation profiles and phosphoproteomics, we generated mitochondrial interaction maps of human pluripotent embryonal carcinoma stem cells and differentiated neuronal-like cells, which presented as two discrete cell populations by single-cell RNA ... [more]
iScience Sep. 27, 2019; 19();1114-1132 [Pubmed: 31536960]
Quantitative Score
- 1.610516286 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Protein pairs with Sigma LLS score >= 1.45 derived from Ntera2 embryonic carcinoma stem cells (ECSC)
Curated By
- BioGRID